Millions of patients suffer from chronic debilitating Pain. Chronic Pain due to diseases like arthritis, fibromyalgia, and MS can prevent daily functioning and quality of life. For a sufferer of arthritis, joint inflammation and degeneration cause stiffness and Pain.
Fibromyalgia is challenging as physical Pain is spread around the body, accompanied by fatigue, sleep problems, and psychological distress. MS interferes with communication between the brain and the body. Its neurological signs involve excruciating Pain. As chronic as some pain conditions are, people have turned to Cannabidiol-CBD, a nonpsychoactive cannabis substance.
Mechanism of Pain Relief by CBD
CBD acts upon the human body through a complex system of receptors, enzymes, and endogenous cannabinoids and actions implemented by these in keeping homeostasis. The most responsive to CBD are ECS receptors CB1 and CB2. The vast majority of CB1 receptors, which govern Pain, mood, and memory, are located in the brain and nervous system.
More CB2 receptors, scattered in peripheral organs, activate the immune system and inflammation. CBD inhibits these receptors to provide some relief from Pain and inflammation, so it is comforting. The best CBD can also boost anandamide levels by stopping its reabsorption.
Evidence Shows CBD Eases Chronic Pain
Several clinical studies have been conducted to explore the use of CBD for chronic Pain. A systematic review in Pain examined 47 trials of CBD preparation and concluded that it is effective in pain reduction in arthritis, fibromyalgia, and neuropathic Pain.
It was also reported to reduce chronic Pain by 30% more than the placebo. In a randomized, double-blind, placebo-controlled study with MS patients, CBD-enriched oil notably diminished discomfort due to spasticity by 30%. Localized CBD treatment has been proven to decrease joint inflammation and reduce the behaviors due to Pain in arthritic rats; therefore, a topical application was provided for that purpose.
CBD and Arthritis Treatment
CBD is one of the primary therapies applied against arthritis, which is a prevalent chronic pain condition. Studies suggest that CBD also decreases joint inflammation, which in turn reduces Pain and enhances functioning. Topically, CBD diminishes osteoarthritis-related joint Pain and inflammation without causing harm to other body parts.
PA research indicated that CBD is able to mitigate nerve damage besides reducing arthritis-related Pain. More human clinical experiments are required to confirm these findings further. More so, patients’ testimonies and anecdotal reports point out that CBD may also help patients reduce their usage of prescription-based pharmaceuticals like opioids for chronic Pain.
CBD Challenges and Complications
The potential of best CBD effects in managing chronic Pain appears promising, though disorders exist. This principle is mostly based on a lack of standardization in the products of CBD. Variability in terms of potency, purity, and formulation may cause adverse effects and variable results. CBD may interact with other drugs; therefore, patients should involve health experts in the decision-making process.
